Nis thyroid
WebOct 12, 2024 · The NIS is a membrane glycoprotein that transports two sodium ions and one iodide ion into the cytosol of benign and tumorous thyroid cells from extracellular fluid (1–3). Since radioiodine also can be taken up by the NIS, radioiodine can be used to visualize or selectively kill DTC cells. WebMay 30, 2024 · Radioiodine therapy (RAI) is a standard and effective therapeutic approach for differentiated thyroid cancers (DTCs) based on the unique capacity for iodide uptake …
Nis thyroid
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WebFeb 10, 2024 · Active iodide (I-) transport in both the thyroid and some extrathyroidal tissues is mediated by the Na + /I-symporter (NIS). In the thyroid, NIS-mediated I-uptake plays a pivotal role in thyroid hormone (TH) biosynthesis. THs are key during embryonic and … WebThe sodium-iodide symporter (NIS) is a member of the sodium/solute symporter family that actively transports iodide across the membrane of the thyroid follicular cells. In 1996, NIS mRNAs from rats 52 and humans 53 were isolated. The human gene (SLC5A5) maps to chromosome 19p13.2-p12.
WebThe NIS protein is found primarily in the thyroid gland, a butterfly-shaped tissue in the lower neck. The thyroid gland produces and releases iodide-containing thyroid hormones that … WebOct 31, 2012 · NIS-mediated iodide uptake also forms the basis for the diagnostic nuclear imaging and radioiodine therapy for thyroid diseases. Radioiodine therapy following NIS gene transfer was shown to be efficient in nonthyroid, especially, liver cancer models. NIS is expressed in many cancers, among them cancer of the thyroid, breast, and liver .
WebNov 14, 2024 · Given the highly significant role of NIS (SLC5A5) in the physiology and the cancer pathogenesis process, this paper’s objective is to provide a comprehensive … WebJan 28, 2024 · Recently, ER stress induced by tunicamycin (TM) was reported to inhibit the expression of key genes involved in thyroid hormone synthesis, such as sodium/iodide symporter (NIS), thyroid peroxidase (TPO) and thyroglobulin (TG), and their regulators such as thyrotropin receptor (TSHR), thyroid transcription factor-1 (TTF-1), thyroid transcription …
WebDec 10, 2024 · Peripheral neuropathy may cause pain, numbness and tingling in the arms and legs. Infertility. Low levels of thyroid hormone can interfere with ovulation, which can …
WebDue to the biological role of NIS in thyroid cells, its expression becomes fundamental for the clinical application of radioiodide in the diagnosis and ablation treatment of a variety of benign and malignant thyroid diseases . In the present study, we provide evidence supporting the role of CREB3L1-in the modulation of NIS gene expression and ... randy birdsong missourirandy birdwhistellWebMay 30, 2024 · thyroid cancer; radioiodine therapy; NIS; reactive oxygen species 1. Introduction The unique ability of the thyroid gland to accumulate iodide (I −) is the basis of radioiodine (RAI) therapy, which has been used for decades as an effective therapy for differentiated thyroid cancer (DTC) treatment [ 1, 2 ]. randy birdsong wifeWebFeb 27, 2024 · Conclusions: The findings of this preclinical study showed that ALK fusion-induced downregulation of NIS, the prerequisite of RAI refractoriness, could be reversed in thyroid cells by either direct inhibition of ALK or its downstream signaling pathways. randy birkes obituary sioux cityWebMay 10, 2024 · The pathway controls the expression of NIS, Tg, TPO and TSHR, through thyroid-specific transcription factors , and regulates Tg macrocytosis and … overwatch soldierWebSep 8, 2024 · NIS ability to concentrate iodine is exploited to treat thyroid tumors and their metastases. Thus, a better understanding of how NIS expression/activity is controlled will help to design strategies to restore radioiodine uptake in RAIR tumors. Multiple mechanisms are responsible for NIS loss of function in thyroid carcinomas (TCs). overwatch sombra ageWebNIS is a fundamental plasma membrane glycoprotein with 13 trans-membrane domains that actively transfers both sodium and iodide together through the cytosol from extracellular-fluid by facilitated diffusion and the sodium/potassium ATPase pump; the action of NIS is moved by low internal sodium concentration in thyroid epithelial cells. 1,2 overwatch sombra counter