WebSep 29, 2024 · Interferon-stimulated gene 15 (ISG15) is a ubiquitin-like protein that is covalently conjugated to many substrate proteins in order to modulate their functions; this conjugation is called ISGylation. Several groups reported that the ISGylation of hepatitis C virus (HCV) NS5A protein affects HCV repl … WebIsolation is the near or complete lack of social contact by an individual.. Isolation or isolated may also refer to: . Sociology and psychology. Isolation (health care), various measures …

National Center for Biotechnology Information

Interferon-stimulated gene 15 (ISG15) is a 17 kDA secreted protein that in humans is encoded by the ISG15 gene. ISG15 is induced by type I interferon (IFN) and serves many functions, acting both as an extracellular cytokine and an intracellular protein modifier. The precise functions are diverse and vary among … See more The ISG15 gene consists of two exons and encodes for a 17 kDa polypeptide. The immature polypeptide is cleaved at its carboxy terminus, generating a mature 15 kDa product that terminates with a LRLRGG See more After induction by type I interferon, ISG15 can be found in three forms, each with unique functions: Extracellular cytokine See more ISG15 was originally identified in the late 1970s as a 15-kDa protein produced in response to type I interferon, a potent class of antiviral cytokines. Given the molecular weight, it was originally termed ‘a 15-kDa protein’, but later renamed interferon … See more • Overview of all the structural information available in the PDB for UniProt: P05161 (Human Ubiquitin-like protein ISG15) at the PDBe-KB See more ISG15-deficiency is a very rare genetic disorder caused by mutations of the ISG15 gene. It is inherited with an autosomal recessive pattern and is classified as a primary immunodeficiency or inborn error of immunity. Patients present in childhood with infectious, See more • Dastur A, Beaudenon S, Kelley M, Krug RM, Huibregtse JM (February 2006). "Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells". The Journal of Biological Chemistry. 281 (7): 4334–8. doi: • Bektas … See more WebJun 4, 2024 · Post-translational modification (PTMs) of proteins by ubiquitin and ubiquitin-like modifiers such as interferon-stimulated gene 15 (ISG15) and small ubiquitin-related … id picture price philippines

Negative regulation of the RIG-I signaling by the ubiquitin

WebThe interferon-stimulating gene 15 (ISG15) protein is a ubiquitin-like protein induced by interferons or pathogens. ISG15 can exist in free form or covalently bind to the target … WebNov 24, 2016 · ISGylation inhibits exosome secretion. To analyse the role of ISGylation on exosome production, we first treated Jurkat T cells with IFN-I, to induce ISG15 expression … WebAug 25, 2024 · The antiviral effects of ISG15 conjugation to targets (ISGylation) include blocking the entry and replication of different pathogens, DNA repair, autophagy, protein … id picture name tag